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Absidia sp. - A zygomycete fungus which
is considered common to the indoor environment. Reported to be allergenic.
May cause mucorosis in immune compromised individuals. The sites of infection
are the lung, nasal sinus, brain, eye, and skin. Infection may have multiple
sites. Absidia cormbifera has been an invasive infection agent in AIDS
and neutropenic patients, as well as, agents of bovine mycotic abortions,
and feline subcutaneous abscesses. Acremonium species may be confused with
Fusarium species that primarily produce microconidia in culture. Fusarium
genera are generally much more rapid growers and produce more aerial mycelium.
Acremonium sp. (Cephalosporium sp.)
- Reported to be allergenic. Can produce a trichothecene toxin which is
toxic if ingested. It was the primary fungus identified in at least two
houses where the occupant complaints were nausea, vomiting, and diarrhea.
Asexual state of Emericellopsis sp., Chaetomium sp., and Nectripsis sp.
It can produce mycetomas, infections of the nails, onychomycosis, corneal
ulcers, eumycotic mycetoma, endophthalmitis, meningitis, and endocarditis.
Acrodontium salmoneum - Reported to
be a fairly common airborne fungus and is considered to be allergenic.
Can produce a trichothecene toxin which is toxic if ingested. It was the
primary fungus identified in at least two houses where the occupant complaints
were nausea, vomiting, and diarrhea. It can produce mycetomas, infections
of the nails, onychomycosis, corneal ulcers, eumycotic mycetoma, endophthalmitis,
meningitis, and endocarditis. It is the asexual state of Emericellopsis
sp., Chaetomium sp., and Nectripsis sp.
Alternaria sp. - Extremely widespread
and ubiquitous. Outdoors it may be isolated from samples of soil, seeds,
and plants. It is commonly found in outdoor samples. It is often found
in carpets, textiles, and on horizontal surfaces in building interiors.
Often found on window frames. The species Alternaria alternata is capable
of producing tenuazonic acid and other toxic metabolites which may be associated
with disease in humans or animals. Alternaria produces large spores having
sizes between 20 - 200 microns in length and 7 - 18 microns in width, suggesing
that the spores from this fungi are deposited in the nose, mouth, and upper
respiratory tract. It may be related to bakers asthma. It has been associated
with hypersensitivity pneumoniti, sinusitis, deratomycosis, onychomycosis,
subcutaneous phaeohyphomycosis, and invasive infection. Common cause of
extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms
include edema and bronchiospasms, chronic cases may develop pulmonary emphysema.
Aphanoascus fulvescens - Extremely widespread
in soil, animal skin scrapings, and dung. Is often associated with birds
nests and feathers. Should be considered an allergen. This fungus has also
been documented in skin infections. No toxic related diseases are of record
to date.
Apophysomyces elegans - Extremely widespread
in soil and decaying vegetation. Should be considered an allergen. This
fungus has also been documented in various zygomycosis including necrotizing
fascitis, osteomyelitis, and angioinvasion. Most cases are acquired through
the tramatic implantation of the fungus. No toxic related diseases are
of record to date.
Arthrinium phaeospermum - Widespread
saprophyte on dead plant material, particularly swampy grasses. Should
be considered an allergen. This fungus has also been documented in various
subcutaneous infections. No toxic related diseases are of record to date.
Arthrographis spp. - Extremely widespread
in soil and decaying vegetation. Arthrographis cuboidea and A. kalrae should
be considered to be allergens. A kalrae has been documented in onychomycosis
and has been recovered from the skin, nails, and respiratory sites but
has not been established as an etiological agent. No toxic related diseases
are of record to date.
Ascomycete. - One of the major classes
of fungal organisms. This class contains the the"sac fungi" and yeasts.
Some ascomycete spores can be identified by spore morphology, however;
some care should be excersised with regard to specific identification.
Many ascomycete spores are reported to be allergenic.
Aspergillus sp. - A genus of fungi containing
approximately 150 recognized species. Members of this genus have been recovered
from a variety of habitats, but are especially common as saprophytes on
decaying vegetation, soils, stored food, feed products in tropical and
subtropical regions. Some species are parasitic on insects, plants and
animals, including man. Species within this genus have reported Aw's (water
activities) between 0.75 - 0.82. All of the species contained in this genus
should be considered allergenic. Various Aspergillus species are a common
cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute
symptoms include edema and bronchiospasms. Chronic cases may develop pulmonary
emphysema. Members of this genus are reported to cause a variety of opportunistic
infections of the ears and eyes. Sever pulmonary infections may also occur.
Many species produce mycotoxins which may be associated with disease in
humans and other animals. Toxin production is dependent on the species
or a strain within a species and on the food source for the fungus. Some
of these toxins have been found to be carcinogenic in animal species. Several
toxins are considered potential human carcinogens.
Aspergillus alliaceus- This species
is not commonly reported from nature and is not considered common to indoor
environments. It has been isolated from soils in desert areas, grassland
or cultivated soils, cacti, onion, and garlic bulbs. This fungus should
be considered allergenic. No toxic or invasive diseases have been documented
to date.
Aspergillus auricomus- This species
was originally isolated from an aqueous solution of potassium iodidie.
It has also been isolated from cottonseed in Arizona. This species is not
considered common to indoor environments. This fungus should be considered
allergenic. No toxic or invasive diseases have been documented to date.
Aspergillus caespitosus - This species
is not considered common to indoor environments. It has been predominantly
isolated from soils but has also been isolated from sugarcane bagesse.
This fungus should be considered allergenic. No toxic or invasive diseases
have been documented to date.
Aspergillus caesiellus - This species
is not considered common to indoor environments. It has been predominantly
isolated from soils. This fungus should be considered allergenic. No toxic
diseases have been documented to date. This species has been reported as
an opportunistic pathogen.
Aspergillus candidus - This species
considered common to indoor environments. It occurs predominantely in tropical
and subtropical regions in stored foods and feedstuffs such as wheat, corn,
barely, sorghum, rice, peanuts, dried macaroni and spaghetti, refrigerated
dough products, and flour. It has also been isolated from soils. It has
an Aw (water activity) of 0.75 and Conidia (spores) dimensions 2.5-4 microns.
This fungus should be considered allergenic. This species has been reported
as an opportunistic pathogen including onychomycosis, otomycosis, and invasive
aspergillosis. It has also been reported to produce the toxin petulin which
may be associated with disease in humans and other animals.
Aspergillus carbonarius - This distinctive
species has not been commonly reported. It has been isolated from mud and
wood in mangrove swamps, soil, and polluted water. This species is not
considered common to indoor environments. This fungus should be considered
allergenic. No toxic or invasive diseases have been documented to date.
Aspergillus carneus - This species is not considered common to indoor
environments. It has been predominantly isolated from tropical and subtropical
soils. This fungus should be considered allergenic. No toxic diseases have
been documented to date. This species has been reported as an opportunistic
pathogen.
Aspergillus cervinus - This species
has not been commonly reported. It has been isolated from tropical rainforest
soils in Malaya, Puerto Rico, New Zealand, Wisconsin, and India. This species
is not considered common to indoor environments. This fungus should be
considered allergenic. No toxic or invasive diseases have been documented
to date.
Aspergillus clavatus - This distinctive
species is a common soil fungus with widespread distribution in soils in
warmer climates. It also is quite widely distributed in some kinds of foods,
especially cereals. This species is not considered common to indoor environments,
however; it has been frequently associated with the brewing industry. This
fungus should be considered allergenic. No toxic or invasive diseases have
been documented to date.
Aspergillus deflectus - This species
is not considered common to indoor environments. It has been predominantly
isolated from tropical and subtropical soils. This fungus should be considered
allergenic. No toxic diseases have been documented to date. This species
has been reported as an opportunistic pathogen.
Aspergillus flavipes - This species
may be recovered from indoor environments. It has been predominantly isolated
from tropical and subtropical soils and decaying vegetation, however; it
has also been isolated from deteriorated cotton fabric. This fungus should
be considered allergenic. No toxic diseases have been documented to date.
This species has been reported as an opportunistic pathogen associated
with cutaneous aspergillosis and osteomyelitis.
Aspergillus flavus - This species may
be recovered from the indoor environment. It has worldwide distribution
but is predominantly a tropical to subtropical fungus apparently more common
in cultivated than uncultivated soil. It colonizes on decaying vegetation,
crop seeds and many other substrates. It grows on Asthmay corn and peanuts
and can also be found in other foods and dairy products. It has been reported
in water damaged carpets. It has also been reported as an insect and animal
pathogen. This fungus has an Aw (water activity) of 0.78. and conidia (spores)
dimensions 3-6 microns or 3-5 microns. This fungus should be considered
allergenic. Its presence has been associated with reports of asthma. Approximately
50% of the strains are capable of producing a group of mycotoxins - in
the aflatoxin group. Aflatoxins are known animal carcinogen. There is limited
evidence to suggest that this toxin is also a human carcinogen. The production
of the fungal toxin is dependent on the growth conditions and on the substrate
used as a food source. The toxin is poisonous to humans by ingestion and
may directly affect the liver. Experiments have indicated that it is teratogenic
and mutagenic. This fungus may also result in disease via inhalation and
is associated with aspergillosis of the lungs and/or disseminated aspergillosis.
This fungus is occasionally identified as the cause of corneal, otomycotic,
and nasoorbital infections.
Aspergillus foetidus - This species
is not commonly reported from nature and is not considered common to indoor
environments. It has been used in several industrial processes including
koji for shochu and enzyme production. This fungus should be considered
allergenic. No toxic or invasive diseases have been documented to date.
Aspergillus fumigatus - This species
may be recovered from the indoor environment. It has worldwide distribution
and grows over a wide range of temperatures. It has been recovered from
soils, plants, seeds, sludge, wood chips, compost, cotton, and penguin
excreta. It is commonly found outdoors in compost piles with temperatures
higher than 40 degrees C, in mild to warm soils and on cereals. This fungus
has an Aw (water activity) of 0.82 with an optimum > 0.97. Conidia (spores)
have dimensions of 2-3.5 microns. This fungus should be considered allergenic,
however; it should be considered as a principle cause for both invasive
and allergic aspergillosis. This organisms will particularly affect individuals
who are immune compromised. It is considered a true human pathogen. No
toxic diseases have been documented to date.
Aspergillus japonicus - This species
is not commonly reported from nature and is not considered common to indoor
environments. It has been isolated from subtropical and tropical soils
and also submerged organic debris. This fungus should be considered allergenic.
No toxic or invasive diseases have been documented to date.
Aspergillus kanagawaensis - This species
is not commonly reported from nature and is not considered common to indoor
environments. It has been isolated from soils in hemlock and jack pine
forest in Wisconsin. Has also been isolated from soils in Japan. This fungus
should be considered allergenic. No toxic or invasive diseases have been
documented to date.
Aspergillus glaucus - This species may
be recovered from the indoor environment. It has widespread distribution
in subtropical regions. It has been recovered in nature from soils and
on plants. This fungus can grow at low moisture levels and has also been
isolated from grains, sugary food products, meat, wool, dried foods, and
leather. It has been reported as a common outdoor fungus in the winter.
The conidia (spores) for this fungus have dimensions of 5-6.5 microns and
is the imperfect stage of the ascomycetous fungus Eurotium sp. It is reported
to be allergenic. This species is only occasionally pathogenic and has
been associated with sinusitis, otitis, cerebral, orofacial, and pulmonary
infections. No toxic diseases have been documented to date.
Aspergillus nidulans - This species
is not considered common to indoor environments. It has been frequently
isolated from tropical and subtropical soils but less frequently from other
areas. This fungus has an Aw (water activity) of 0.78 with conidia (spores)
having dimensions of 2-4 microns. It is reported to be allergenic. This
species has been reported in a variety of animal and human infections including
invasive and systemic disease including aspergillosis of the lungs and/or
disseminated aspergillosis. It can produce the mycotoxin sterigmatocysti
that has been shown to produce liver and kidney damage in lab animals.
Aspergillus niger - This species is
considered common to indoor environments. It is widespread in the soil
and on plants and is also considered a common contaminant of foods. It
has a musty odor. It is commonly found in the environment on textiles,
in soils, grains, fruits and vegetables isolated from tropical and subtropical
soils but less frequently from other areas. This fungus has an Aw (water
activity) of 0.77 with an optimum > 0.97 . Conidia (spores) have dimensions
of 3.5 - 5 microns or 4 to 5 microns. It is reported to be allergenic.
It is common in secondary organisms following bacterial otitis and is more
commonly being implicated in pulmonary disease in immunocompromised hosts.
It has also been reported to cause skin infections.
Aspergillus niveus - This species is
not considered common to indoor environments. It has been predominantly
isolated from soils and appears to be widely distributed. This fungus should
be considered allergenic. No toxic or invasive diseases have been documented
to date.
Aspergillus ochraceus - This species
is considered common to indoor environments. It is widespread in cultivated
soils, but has also been documented in uncultivated soils, grains, and
salted food products. It is not usually associated with decaying vegetation.
This fungus has an Aw (water activity) of 0.77 with conidia (spores) having
dimensions of 2.5 - 3 microns. It is reported to be allergenic. It has
not been reported as causing any invasive disease to date. This fungus
can also produce ochratoxin A, which may produce ochratoxicosis in humans.
This is also known as Balkan nephropathy, a disorder that affects the kidneys.
The toxin is produced at optimum growth conditions at 25 degrees C and
high moisture conditions. The ochratoxin may also be produced by other
Aspergillus sp. and Penicillium sp. Other toxins which can be produced
by this fungus include penicillic acid, xanthomegnin and viomellein. These
are all reported to be kidney and liver toxins.
Aspergillus oryzae - This species may
be considered common to some indoor environments. It has been predominantly
isolated from soils, vegetative plant parts, seeds, and cotton fabrics.
It is also used in food fermentations, in the production of saki, shoyu,
miso, and soy sauce, and as a source of industrial enzymes. This fungus
should be considered allergenic. No toxic or invasive diseases have been
documented to date.
Aspergillus ostianus - This species
is not considered common to indoor environments. It has been isolated from
animal feed, chicory seed, and gram seed storage. This fungus should be
considered allergenic. No toxic or invasive diseases have been documented
to date.
Aspergillus paradoxus - This species
is considered a very uncommon species that is not considered typical of
indoor environments. It has been isolated from opossum dung and soil. This
fungus should be considered allergenic. No toxic or invasive diseases have
been documented to date.
Aspergillus parasiticus - This species
is not considered common to indoor environments. It has been isolated from
cultivated soils. Lack of reported isolations may be due in part to the
failure of investigators to differentiate A. parasiticus from A. flavus.
It has been isolated more frequently from seeds, other plants, and insects.
This fungus should be considered allergenic. No invasive diseases have
been documented to date. Some strains are capable of producing a group
of mycotoxins - in the aflatoxin group. Aflatoxins are known animal carcinogen.
There is limited evidence to suggest that this toxin is a human carcinogen.
The toxin is poisonous to humans by ingestion. Experiments have indicated
that it is teratogenic and mutagenic. It is toxic to the liver. The production
of the fungal toxin is dependent on the growth conditions and on the substrate
used as a food source.
Aspergillus penicilloides - This species
is not generally considered common to indoor environments, however; this
may be related to its xerophyilic nature (can grow in areas with low water
activity) and that it grows very poorly on usual laboratory media. Therefore,
it may often be overlooked in typical investigations. Reports in the literature
are quite rare, however, if suitable media are used, the species can be
recovered in large numbers from a variety of dried foods, house dust, spices,
and cereals. This fungus should be considered allergenic. It has also been
reported as an opportunistic pathogen. No toxic diseases have been documented
to date.
Aspergillus puniceus - This species
is not commonly reported from nature and is not considered common to indoor
environments. It has been isolated from soils. This fungus should be considered
allergenic. No toxic or invasive diseases have been documented to date.
Aspergillus restrictus - This species
is not generally considered common to indoor environments, however; this
may be related to its slow growing nature. Therefore, it may often be overlooked
in typical investigations. It has been isolated from a variety of subtrates
including soil, cotton goods and fruit juices, and from air. This fungus
should be considered allergenic. It has also been reported as an opportunistic
pathogen and associated with endocarditis, onychomycosis, and pulmonary
aspergillosis. No toxic diseases have been documented to date.
Aspergillus sclerotiorum - This species
is not considered common to indoor environments. It has been isolated from
tropical and subtropical soils. This fungus should be considered allergenic.
No toxic or invasive diseases have been documented to date.
Aspergillus sojae - This species is
not considered common to indoor environments. To date, it has only been
isolated from koji fermentations. This fungus should be considered allergenic.
No toxic or invasive diseases have been documented to date.
Aspergillus sparsis - This species is
not considered common to both outdoor or indoor environments. It has been
isolated from soil. This fungus should be considered allergenic. No toxic
or invasive diseases have been documented to date.
Aspergillus sydowi - This species has
worldwide distribution. Its primary habitat is the soil, but it has been
reecovered from a variety of other substrates. Found in warmer soil and
in grains, straw, cotton, and decomposing vegetation. It appears to be
less common in foods than A. versicolor. This fungus should be considered
allergenic. This fungus is associated with aspergillosis of the lungs and/or
disseminated aspergillosis otomycosis (ear infection) and onychomycosis
(infection of finger or toe nails). This fungus can produce the toxins
patulin and citrinin which may be associated with disease in humans and
other animals.
Aspergillus tamarii - This species is
not considered common to both outdoor or indoor environments. It was originally
isolated from tamari sauce. It is fairly common soil fungus and has been
isolated from seeds of various crops and other substrates. This fungus
should be considered allergenic. No toxic or invasive diseases have been
documented to date.
Aspergillus terreus - This fungus has worldwide distribution in
soils, but is more abundant in tropical and subtropical regions rather
than temperate regions. It is also common in cultivated soils and forests
than grasslands. It is common in stored crops and has been isolated from
other foodstuffs. It should be considered allergenic. Invasive bronchopulmonary
aspergillosis, onychomycosis, cutaneous, ophthalmic, and disseminated mycosis
have been documented. No toxic or invasive diseases have been documented
to date.
Aspergillus unguis - This species is not considered common but have
been isolated from a variety of substrates including man, shoe leather,
and sesame seeds. This fungus should be considered allergenic. No toxic
or invasive diseases have been documented to date.
Aspergillus ustus - This species is
not considered common in habitats other than tropical or subtropical soils.
This fungus should be considered allergenic. This species is only occasionally
pathogenic and has been associated with otitis media, burns, and disseminated
infections. No toxic diseases have been documented to date.
Aspergillus versicolor - This is a widely
distributed fungus commonly found in soil, hay, cotton, dairy products,
dried cereals, nuts, and especially spices. It is often considered to be
one of the most widely distributed species of Aspergillus. This fungus
should be considered allergenic. This species is pathogenic and has been
associated with onychomycosis and invasive aspergillosis. It can produce
a mycotoxin sterigmatocystin and cyclopiaxonic acid. These toxins can cause
diarrhea and upset stomach. It is also reported to be a kidney and liver
carcinogen.
Aspergillus wentii - This species is
considered common with its main distribution in tropical or subtropical
soils. It has also been isolated from plant litter and seeds. This fungus
should be considered allergenic. This species is only occasionally pathogenic
and has been associated with otitis media, burns, and disseminated infections.
No toxic diseases have been documented to date.
Aureobasidium pullulans- A cosmopolitan fungus with the main habitat apparently on the aerial parts of plants. Frequently found in moist environments. This fungus should be considered allergenic. This species has been associated with deratitis, peritonitis, pulmaonary infection, and invasive disease in AIDS patients. Probably aquired by traumatic implantation. May be recovered as a contaminant from human cutaneous sites. No toxic diseases have been documented to date.
Basidiomycetes - One of the major classes
of fungal organisms. This class contains the mushrooms, shelf fungi, puffballs,
and a variety of other macrofungi. It is extremely difficult to identify
a specific genera of mushrooms by using standard culture plate techniques.
Some basidiomycete spores can be identified by spore morphology, however;
some care should be exercised with regard to specific identification. Many
basidiomycete spores are reported to be allergenic.
Basidiobolus - Has been isolated from
decaying plants, soil, and from the fecal materials of frogs, reptiles,
fish, and bats. The relationship of these organisms to human occupied spaces
potentiallly suggests a common present of this genera of fungi in the indoor
environments. Should be considered allergenic. Basidiobolus ranarum rarely
causes disease, but has prinicipally been involved with trunk and extremity
infection of children in tropical countries. No toxic diseases have been
documented to date.
Beauveria - Widespread in the soil with
various species being parasites of insects, the most notable geing Beauveria
bassiana which affects the silkworm. Not considered to be common to indoor
environments. Should be considered allergenic. Reported to cause mycotic
keratitis and occasional pulmonary infections. No toxic diseases have been
documented to date.
Bipolaris sp. - A widespread fungus
that is most frequently associated with grasses, plant material, decaying
food, and soil. It is common to both indoor and outdoor environments. Older
obsolete names include Drechslera and Helminthosporium. This fungus produces
large spores which would be expected to be deposited in the upper respiratory
tract. Various species of this fungus can produce the mycotoxin - sterigmatocystin
which has been shown to produce liver and kidney damage when ingested by
laboratory animals.
Bipolaris australiensis - A widespread
fungus that is most frequently associated with grasses, plant material,
and soil. Should be considered allergenic. Has also been reported as an
infrequent agent of phaeohyphomycosis, particularly fungal sinusitis. It
can occasionally cause a corneal infection of the eye.
Bipolaris cynodontis. - A widespread
fungus that is most frequently associated with bermuda grass. Recoveries
have been made from human sinus and eyes, however; its exact role as a
etiological agent remain unclear.
Bipolaris hawaiiensis - A widespread
fungus that is most frequently associated with grasses, plant material,
and soil. Should be considered allergenic. Common etiologic agent in fungal
sinusitis. Also reported cases of pulmonary and cerebral disease, menigoencephalitis,
and endophthalmitis. This organisms appears to be extremely agressive in
some settings, possibly neutrotropic.
Bipolaris spicifera - A widespread
fungus that is most frequently associated with grasses and plant material,
and soil. Should be considered allergenic. Common etiologic agent in fungal
sinusitis. Also been reported as an agent of phaeohyphomycosis, particularly
fungal sinusitis. Disease also includes endocarditis, keratitis, osteomyelitis,
peritonitis, and meningoencephalitis. This is the most common Bipolaris
species implicated in human disease.
Blastomyces sp. - Blastomyces dermatitidis-
Rare environmental isolates have been found in moist soil with high organic
content. Important human pathogen. It is a thermally dimorphic fungus which
has filamentous fungus when grown at 25 degrees C and a yeast form at 37
degrees C. Causes Blastomycosis in humans and animals involving pulmonary
invasion, followed by cutaneous, osteoarticular and genitourinary disease.
No toxic diseases have been documented to date.
Blastoschizomyces sp. - Blastoschizomyces
capitatus found in the soil, beach sand, as a normal flora of the skin,
respiratory and digestive tracts of humans. Invasive and disseminated infections
have been reported in immunocompromised patients. Cases of encephalitis
and osteomyelitis have also been reported. No toxic diseases have been
documented to date.
Botrytis sp. - It is parasitic on plants, vegetables, and soft fruits
but may also be found in soil. Reported to be allergenic. No toxic or invasive
diseases have been documented to date.
C
Candida sp. - This genus contains a
variety of organisms that have been isolated from the environment, as well
as human skin and mucous membranes.
Candida albicans - Found in animals
and in man. Has been isolated from the skin and mucosa of man, but has
also been recovered from leaves, flowers, water, and soil. Reported to
be allergenic. A common cause of superficial infection, oral and vaginal
infection, sepsis, and disseminated disease. Cells from the organism are
usually not airborne and are considered to be a normal component of the
flora of mouth and other mucous membranes in the body. Thrush and other
diseases caused by Candida albicans usually occur after prolonged treatment
with antibiotics or steroids. No toxic diseases have been documented to
date.
Candida ciferrii - Found in soils.
Considered to be allergenic. A common cause of superficial infection isolated
from ears, skin, nails, and eyes. No toxic diseases have been documented
to date.
Candida glabrata - Found associated
with man, mammals, birds, fruit juices, and insects. Considered to be allergenic.
Implicated in sepsis, persistent urinary tract infections, and refracatory
vaginitis. A major emerging pathogen in nosocomial disease. No toxic diseases
have been documented to date.
Candida guilliermondii - Found associated
with man and other mammals, brewery products, vegetation, and insects.
Considered to be allergenic. Implicated in sepsis, urinary tract infections,
respiratory speciments, brain abscesses, skin and nail cultures. No toxic
diseases have been documented to date.
Candida kefyr - Found in grains, dairy
products, man and other mammals. Considered to be allergenic. Rare cause
of human mycoses. May cause blood sepsis, invasive disease, and vaginitis,
and urinary tract infections. No toxic diseases have been documented to
date.
Candida krusei - Found in air samples,
dairy products, soil, man and other mammals. Considered to be allergenic.
Involved in sepsis and disseminated, invasive disease, includingendocarditis,
peritonitis, vaginitis, and urinary tract infections. No toxic diseases
have been documented to date.
Candida lambica - Found in dairy products,
fruit juice, water, birds, and man. Considered to be allergenic.
Candida lipolytica - Found in man and
other mammals, corn, olives, and hydrocarbons. Considered to be allergenic.
Implicated in sepsis, thrombophlebitis, and chronic sinusitis. No toxic
diseases have been documented to date.
Candida lusitaniae - Found in man and
other mammals, birds, citris fruits, and pears. Considered to be allergenic.
Implicated in sepsis, especially in immunocompromised patients with underlying
malignancy, and urinary tract infection. No toxic diseases have been documented
to date.
Candida parapsilosis - Found in man
and other mammals, tea, fruit juices, and water. Considered to be allergenic.
Implicated in sepsis. Associated with burn infections and endocarditis.
No toxic diseases have been documented to date.
Candida rugosa - Found in dairy products,
feces, seawater, and insects. Considered to be allergenic. Implicated in
sepsis. Implicated in fungemia, burn infection, and glandular infections
in cattle. No toxic diseases have been documented to date.
Candida tropicalis - Found in humans
and other mammals, fruit, and water. Considered to be allergenic. Considered
a true pathogen of immunocompromised hosts. Implicated in sepsis, wound
infections, neonatal infections, and disseminated deep tissue infections.
No toxic diseases have been documented to date.
Candida zeylanoides - Found in humans,
soil, meat, fish, and water. Considered to be allergenic. Implicated in
sepsis, endocarditis, fungal arthritis, skin and nail infections. No toxic
diseases have been documented to date.
Cephalosporium sp. - See Acremonium
sp.
Chaetomium sp. - Large ascomycetous
fungus producing perithecia. It is found on a variety of substrates containing
cellulose including paper and plant compost. It can be readily found on
the damp or water damaged paper in sheetrock.
Chaetomium atrobrunneum - This fungus
is found in the soil, air, and on plant debris. Should be considered as
allergenic. Has been implicated in fatal systemic mycoses. The thermophilic,
neurotropic nature of this organisms suggests it is a potentially agressive
pathogen. No toxic diseases have been documented to date.
Chaetomium globosum - This fungus is
found in the soil, air and on plant debris. Should be considered as allergenic.
Is considered an agent of onychomycosis, peritonitis, and cutaneous lesions.
Has been implicated in fatal systemic mycoses. No toxic diseases have been
documented to date.
Chaetomium strumarium - This fungus
is common in warm soil and on plant debris. Should be considered as allergenic.
Has been implicated in fatal brain abscesses in drug abusers. No toxic
diseases have been documented to date.
Chrysosporium spp. - Widespread, common
in the soil and on plants. Rare agents of onychomycosis, skin lesions,
endocarditis, and uncommon agents of the pulmonary mycosis adiaspiromycosis.
No toxic diseases have been documented to date.
Cladophialophora spp. - Widespread,
common in the soil and on plant debris. C. bantiana has been reported as
a neurotropic agent causing cerebral phaeohyphomycosis in the form of brain
abscesses. Skin lesions have also been reported. The organisms has also
been recovered from pulmonary sites. C. boppii has been associated with
skin lesions and a possible cause of chromoblastomycosis. C. carrionii
is almost exclusively associated with chromoblastomycosis, which is generally
restricted to subtropical areas. Most patients have had long-term soil
exposure with repeated trauma and tissue injuries to the feet and legs.
No toxic diseases have been documented to date.
Cladosporium sp. (Hormodendrum sp.)
- Aw (water activity) in the range of 0.84 to 0.88. Most commonly identified
outdoor fungus. The outdoor numbers are reduced in the winter. The numbers
are often high in the summer. Often found indoors in numbers less than
outdoor numbers. It is a common allergen. Indoor Cladosporium sp. may be
different than the species identified outdoors. It is commonly found on
the surface of fiberglass duct liner in the interior of supply ducts. A
wide variety of plants are food sources for this fungus. It is found on
dead plants, woody plants, food, straw, soil, paint and textiles. It can
cause mycosis. Produces greater than 10 antigens. Antigens in commercial
extracts are of variable quality and may degrade within weeks of preparation.
Common cause of extrinsic asthma (immediate-type hypersensitivity: type
I). Acute symptoms include edema and bronchiospasms, chronic cases may
develop pulmonary emphysema.
Cladosporium cladosporioides - Widespread
distribution. Together with C. herbarum compose the most common species
on dead organic matter and in the air. It is found on dead plants, woody
plants, food, straw, soil, paint and textiles. Reported allergen. Has been
implicated in pulmonary and cutaneous infections, possible sinus infection,
mixed disseminated infections. No toxic diseases have been documented to
date.
Cladosporium herbarum - Widespread
distribution. Together with C. cladosporioides compose the most common
species on dead organic matter and in the air. It is found on dead plants,
woody plants, food, straw, soil, paint, and textiles. Reported allergen.
Has been implicated in cutaneous infections and keatitis. No toxic diseases
have been documented to date.
Cladosporium macrocarpum - Common species
on dead organic matter and in the air. It is found on dead plants, woody
plants, food, straw, soil, paint, and textiles. Reported allergen. No toxic
or invasive diseases have been documented to date.
Cladosporium sphaerospermum - Worldwide
distribution. Considered a secondary invader of plants, textiles, food
and is common to the soil, and air. Reported allergen. Implicated in skin
lesions, corneal ulcer, and onychomycosis.
Cladosporium fulvum
(Fulvia fulva) - Conidia (spores) dimensions 12-47 x 4-10 microns. It is
found on the leaves of tomatoes.
Cryptostroma corticale - Conidia (spores)
dimensions 4-6.5 x 3.5-4 microns. Found on the bark of maple and sycamore
trees and on stored logs.
Conidobolus sp. - Can cause a chronic
inflammatory disease of the nasal mucosa (entomophthoromycosis).
Cunninghamella sp. - Can cause disseminated
and pulmonary infections in immune compromised hosts.
Curvularia sp. - Reported to be allergenic.
It may cause corneal infections, mycetoma and infections in immune compromised
hosts.
D
Dreschlera sp. - Conidia (spores) dimensions
40-120 x 17-28 microns. Found on grasses, grains and decaying food. It
can occasionally cause a corneal infection of the eye.
E
Emericella nidulans - A ubiquitous
soil fungus. Most often isolated from tropical and subtropical climates.
Perfect stage of Aspergillus nidulans. This
fungus should be considered allergenic. No toxic or invasive diseases have
been reported to date.
Emericella quadrillineata- A ubiquitous
soil fungus. Most often isolated from tropical and subtropical climates.
Perfect stage of Aspergillus tetrazonus. This fungus should be considered
allergenic. No toxic or invasive diseases have been reported to date.
Emericella rugulosa- A relatively uncommon
species most commonly isolated from soil. Perfect stage of Aspergillus
rugulovalvus. This fungus should be considered allergenic. No toxic or
invasive diseases have been reported to date.
Epicoccum sp. - Conidia (spores) dimensions
15-25 microns. A common allergen. It is found in plants, soil, grains,
textiles, and paper products.
Epidermophyton sp. - Can cause infections
of skin and nails.
Eurotium amstelodami
- This fungus is frequently encountered in tropical and subtropical regions.
It is frequently reported from soils and dried or concentrated food products.
It is the perfect stage of Aspergillus amstelodami. This fungus should
be considered allergenic. No toxic or invasive diseases have been reported
to date.
Eurotium chevalieri - This fungus is
frequently encountered in tropical and subtropical regions. It is frequently
reported from soils and dried or concentrated food products, leather goods,
cotton, seeds, and other dried products. The fungus is considered to be
a xerophile. It is the perfect stage of Aspergillus chevalieri. This fungus
should be considered allergenic. No toxic or invasive diseases have been
reported to date.
Eurotium rubrum - This fungus is frequently
encountered in tropical and subtropical regions. It is frequently reported
from soils and dried or concentrated food products, leather goods, cotton,
seeds, and other dried products. The fungus is considered to be a xerophile.
It is the perfect stage of Aspergillus rubrobrunneus. This fungus should
be considered allergenic. No toxic or invasive diseases have been reported
to date.
F
Fusarium solani - Aw (water activity)
0.90. Macroconidia (spores) dimensions 27-52 x 4.4-6.8; Microconidia dimensions
8-16 x 2-4 microns. Found in plants and soils. Can produce trichothecene
toxins which may be associated with disease in humans and animals.
Fusarium sp. - Aw (water activity)
0.90. A common soil fungus. It is found on a wide range of plants. It is
often found in humidifiers. Several species in this genus can produce potent
trichothecene toxins (5, 27). The trichothecene (scirpene) toxin targets
the following systems: circulatory, alimentary, skin, and nervous. Produces
vomitoxin on grains during unusually damp growing conditions. Symptoms
may occur either through ingestion of contaminated grains or possibly inhalation
of spores. The genera can produce hemorrhagic syndrome in humans (alimentary
toxic aleukia). This is characterized by nausea, vomiting, diarrhea, dermatitis,
and extensive internal bleeding. Reported to be allergenic. Frequently
involved in eye, skin and nail infections.
G
Geotrichum sp. - Aw (water activity)
0.90. Conidia (spores) dimensions 6-12 x 3-6 microns. Aw (water activity)
0.90. A common contaminant of grains, fruits, dairy products, paper, textiles,
soil and water, and often present as part of the normal human flora. The
species Geotrichum candidum can cause a secondary infection (geotrichosis)
in association with tuberculosis. This rare disease can cause lesions of
the skin, bronchi, mouth, lung, and intestine.
Gliocladium sp. - A fungus which is
structurally similar to Penicillium sp. It is reported to be allergenic.
H
Helminthosporium sp. - Reported to
be allergenic.
Histoplasma sp. - A fungus which has
filamentous growth at 25 degrees C and yeast growth at 37 degrees C. It
is reported to be a human pathogen. It may be associated with birds.
Humicula sp. - Grow on products with
a high cellulose content. These fungi are also found in soil and on plant
debris.
Hyaline Mycelia - Sterile mycelia which
is white or transparent. No fruiting structures are produced by the mycelia.
Visual identification of these organisms is not possible. Often associated
with allergic symptoms.
I-L, still under construction
M
Microsporum sp. - Causes ringworm in
humans.
Monilia sp. - Reported to be allergenic.
This fungus produces soft rot of tree fruits. Other members produce a red
bread Asthma. It is infrequently involved in corneal eye infections.
Mucor sp. - Often found in soil, dead
plant material, horse dung, fruits, and fruit juice. It is also found in
leather, meat, dairy products, animal hair, and jute. A Zygomycetes fungus
which may be allergenic (skin and bronchial tests) (7, 17). This organism
and other Zygomycetes will grow rapidly on most fungal media. May cause
mucorosis in immune compromised individuals. The sites of infection are
the lung, nasal sinus, brain, eye, and skin. Infection may have multiple
sites.
N
Nigrospora sp. - Reported to be allergenic.
O, still under construction
P
Paecilomyces sp. - Commonly found in
soil and dust, less frequently in air. P. variotii can cause paecilomycosis.
Linked to wood-trimmers disease and humidifier associated illnesses. They
are reported to allergenic. Some members of this genus are reported to
cause pneumonia. It may produce arsine gas if growing on arsenic substrate.
This can occur on wallpapers covered with paris green.
Papulospora sp. - This fungi is found
in soil, textiles, decaying plants, manure, and paper.
Penicillium sp. - Aw (water activity)
0.78 - 0.88. A wide number of organisms have placed in this genera. Identification
to species is difficult. Often found in aerosol samples. Commonly found
in soil, food, cellulose, and grains (17, 5). It is also found in paint
and compost piles. It may cause hypersensitivity pneumonitis and allergic
alveolitis in susceptible individuals. It is reported to be allergenic
(skin) (7, 17). It is commonly found in carpet, wallpaper, and in interior
fiberglass duct insulation (NC). Some species can produce mycotoxins. Common
cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute
symptoms include edema and bronchiospasms, chronic cases may develop pulmonary
emphysema.
Periconia sp. - No information available,
more to come.
Phoma sp. - A common indoor air allergen.
It is similar to the early stages of growth of Chaetomium sp. The species
are isolated from soil and associated plants (particularly potatoes). Produces
pink and purple spots on painted walls (3, 17). It may have antigens which
cross-react with those of Alternaria sp. It will grow on butter, paint,
cement, and rubber. It may cause phaeohyphomycosis, a systematic or subcutaneous
disease.
Pithomyces sp. - Grows on dead grass
in pastures. Causes facial eczema in ruminants.
Q, still under construction
R
Rhizomucor sp. - The Zygomycetous fungus
is reported to be allergenic. It may cause mucorosis in immune compromised
individuals. It occupies a biological niche similar to Mucor sp. It is
often linked to occupational allergy. The sites of infection are the lung,
nasal sinus, brain, eye, and skin. Infection may have multiple sites.
Rhizopus sp. - The Zygomycetous fungus
is reported to be allergenic. It may cause mucorosis in immune compromised
individuals. It occupies a biological niche similar to Mucor sp. It is
often linked to occupational allergy. The sites of infection are the lung,
nasal sinus, brain, eye, and skin. Infection may have multiple sites.
Rhodotorula sp. - A reddish yeast typically
found in moist environments such as carpeting, cooling coils, and drain
pans. In some countries it is the most common yeast genus identified in
indoor air. This yeast has been reported to be allergenic. Positive skin
tests have been reported. It has colonized in terminally ill patients.
S
Saccharomyces sp. - Reported to be
allergenic. Baker's Yeast.
Scopulariopsis sp. - It may produce
arsine gas if growing on arsenic substrate. This can occur on wallpapers
covered with paris green. It has been found growing on a wide variety of
materials including house dust. It is associated with type III allergy.
Serpula lacrymans - Common cause of
extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms
include edema and bronchiospasms; chronic cases may develop pulmonary emphysema.
Sporobolomyces sp. - Reported to be
allergenic.
Sporothrix sp. - Can cause sporotrichosis.
Usually only in populations which are immune compromised.
Sporotrichum sp. - Reported to be allergenic.
See also Sporothrix sp. as there is some taxonomic confusion between these
two genera. This genera does not cause sporotrichosis.
Stachybotrys sp. - Aw (water activity) - 0.94, optimum Aw (water activity) - >0.98. Several strains of this fungus (S. atra, S. chartarum and S. alternans are synonymous) may produce a trichothecene mycotoxin- Satratoxin H - which is poisonous by inhalation. The toxins are present on the fungal spores. This is a slow growing fungus on media. It does not compete well with other rapidly growing fungi. The dark colored fungi grows on building material with a high cellulose content and a low nitrogen content. Areas with relative humidity above 55% and are subject to temperature fluctuations are ideal for toxin production. Individuals with chronic exposure to the toxin produced by this fungus reported cold and flu symptoms, sore throats, diarrhea, headaches, fatigue, dermatitis, intermittent local hair loss, and generalized malaise. The toxins produced by this fungus will suppress the immune system affecting the lymphoid tissue and the bone marrow. Animals injected with the toxin from this fungus exhibited the following symptoms: necrosis and hemorrhage within the brain, thymus, spleen, intestine, lung, heart, lymph node, liver, and kidney. The mycotoxin is also reported to be a liver and kidney carcinogen. Affects by absorption of the toxin in the human lung are known as pneumomycosis. This organism is rarely found in outdoor samples. It is usually difficult to find in indoor air samples unless it is physically disturbed. The spores are in a gelatinous mass. Appropriate media for the growth of this organism will have a high cellulose content and a low nitrogen content. The spores will die readily after release. The dead spores are still allergenic and toxigenic. Percutaneous absorption has caused mild symptoms.
Stemphylium sp. - Reported to be allergenic.
Isolated from dead plants and cellulose materials.
Syncephalastrum sp. - Can cause a respiratory
infection characterized by a solid fungal ball.
T
Trichoderma sp. - It is commonly found
in soil, dead trees, pine needles, paper, and unglazed ceramics. It often
will grow on other fungi. It produces antibiotics which are toxic to humans.
It has been reported to be allergenic (7, 17). It readily degrades cellulose.
Trichophyton sp. - Can cause ring worm,
athlete's foot, skin, nail, beard, and scalp (5, 6). Reported to be allergenic.
Found on soil and skin.
Trichothecium sp. - Aw (water activity)
0.90. Conidia (spores) dimensions 12-23 x 8-10 microns. Found in decomposing
vegetation, soil, corn seeds, and in flour. The species Trichothecium roseum
can produce a trichothecene toxin which may be associated with disease
in humans and other animals. Reported to be allergenic.
Tritirachium sp. - Reported to be allergenic.
U
Ulocladium sp. - Has an Aw (water activity)
of 0.89. Isolated from dead plants and cellulose materials. Found on textiles.
V
Verticillium sp. - Conidia (spores)
dimensions 2.3-10 x 1-2.6 microns. Found in decaying vegetation, on straw,
soil, and arthropods. A rare cause of corneal infections.
W
Wallemia sp. - Has an Aw (water activity)
of 0.75. Conidia (spores) dimensions 2.5-3.5 microns. Found in sugary foods,
salted meats, dairy products, textiles, soil, hay, and fruits.
X, still under construction
Y
Yeast - Various yeasts are commonly
identified on air samples. Some yeasts are reported to be allergenic. They
may cause problems if a person has had previous exposure and developed
hypersensitivity. Yeasts may be allergenic to susceptible individuals when
present in sufficient concentrations.
Z, still under construction
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Molds reproduce
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spores land on a damp spot indoors, they may begin growing and digesting
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